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Home / Brands / Starting with C / Cortidelt / Alitretinoin 		 
Alitretinoin
  

An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
BrandsPanretin
Panretin Gel
Panretyn
Panrexin
Renova
Retin-A
Retin-A Micro
Vesanoid
CategoriesAntineoplastic Agents
Keratolytic Agents
ManufacturersEisai inc
PackagersBasilea Pharmaceuticals Corp.
Contract Pharm
Eisai Inc.
Ortho-McNeil-Janssen Pharmaceuticals Inc.
Synonyms9-cis-Retinoic acid
ALRT-1057
BAL4079
Retinoic Acid

indication

For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.

pharmacology

Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.

mechanism of action

Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.

Terms of Use