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Home / Drugs / Starting with A / Anistreplase 		 
Anistreplase
  

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
BrandsEminase (Wulfing Pharma GmbH)
CategoriesThrombolytic Agents
Packagersh
h
Synonymst- PA
t-plasminogen activator
Tissue-type plasminogen activator precursor
tPA

indication

For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction

pharmacology

Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.

mechanism of action

Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.

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