Attapulgite | Genelabs.com

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.

indication

When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.

pharmacology

Attapulgite is an adsorptive magnesium aluminium phyllosilicate which binds to toxins, bacteria and water.

mechanism of action

Attapulgite adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.

drug interactions

Chloroquine: The antiacid decreases the absorption of chloroquine

Clindamycin: The aluminium salt decreases the absorption of lincosamides

Demeclocycline: Formation of non-absorbable complexes

Doxycycline: Formation of non-absorbable complexes

Lincomycin: The aluminium salt decreases the absorption of lincosamides

Minocycline: Formation of non-absorbable complexes

Penciclovir: The multivalent agent decreases the effect of penicillamine

Tetracycline: Formation of non-absorbable complexes

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