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Home / Drugs / Starting with A / Azithromycin

Azithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides.
CategoriesAnti-Bacterial Agents
Other Macrolides
ManufacturersPfizer chemicals div pfizer inc
Pfizer global research development
Pliva inc
Sandoz inc
Teva pharmaceuticals usa
Pfizer central research
App pharmaceuticals llc
Gland pharma ltd
Hospira inc
Pliva hrvatska doo
Sagent strides llc
Teva parenteral medicines inc
Pfizer inc
Inspire pharmaceuticals inc
Mylan pharmaceuticals inc
Teva pharmaceuticals usa inc
Wockhardt ltd
PackagersAdvanced Pharmaceutical Services Inc.
Aidarex Pharmacuticals LLC
Amerisource Health Services Corp.
Apotheca Inc.
APP Pharmaceuticals
AQ Pharmaceuticals Inc.
A-S Medication Solutions LLC
Baxter International Inc.
Cardinal Health
Catalent Pharma Solutions
Comprehensive Consultant Services Inc.
Dept Health Central Pharmacy
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Eon Labs
Greenstone LLC
H.J. Harkins Co. Inc.
Hospira Inc.
Innoviant Pharmacy Inc.
Inspire Pharmaceuticals
Kaiser Foundation Hospital
Lake Erie Medical and Surgical Supply
Liberty Pharmaceuticals
Major Pharmaceuticals
Medisca Inc.
Murfreesboro Pharmaceutical Nursing Supply
Nucare Pharmaceuticals Inc.
Palmetto Pharmaceuticals Inc.
Patheon Inc.
PD-Rx Pharmaceuticals Inc.
Pfizer Inc.
Pharmaceutical Utilization Management Program VA Inc.
Pharmpak Inc.
Physicians Total Care Inc.
Pliva Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Public Health Department Seattle and King County
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Sagent Pharmaceuticals
Sicor Pharmaceuticals
Southwood Pharmaceuticals
Stat Rx Usa
Stat Scripts LLC
Strides Arcolab Limited
Teva Pharmaceutical Industries Ltd.
Tya Pharmaceuticals
UDL Laboratories
US Pharmaceutical Group
Warner Chilcott Co. Inc.
Wockhardt Ltd.
Azithromycin Dihydrate
Azithromycine [French]
Azithromycinum [Latin]
Azitromicina [Spanish]


For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal


Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.

mechanism of action

Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells.


Potentially serious side effects of angioedema and cholestatic jaundice were reported


Hepatic. In vitro and in vivo studies to assess the metabolism of azithromycin have not been performed.


Bioavailability is 37% following oral administration. Absorption is not affected by food. Azithromycin is extensively distributed in tissues with tissue concentrations reaching up to 50 times greater than plasma concentrations. Drug becomes concentrated within macrophages and polymorphonucleocytes giving it good activity against Chlamydia trachomatis.

half life

68 hours

route of elimination

Biliary excretion of azithromycin, predominantly as unchanged drug, is a major route of elimination.

drug interactions

Acenocoumarol: Azithromycin may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.

Anisindione: Azithromycin may increase the anticoagulant effect of anisindione by increasing its serum concentration.

Artemether: Additive QTc-prolongation may occur. Concomitant therapy should be avoided.

Cyclosporine: The macrolide, azithromycin, may increase the effect of cyclosporine.

Dicumarol: Azithromycin may increase the anticoagulant effect of dicumarol by increasing its serum concentration.

Disopyramide: The macrolide, azithromycin, may increase the effect of disopyramide.

Lovastatin: The macrolide antibiotic, azithromycin, may increase the serum concentration of lovastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lovastatin if azithromycin is initiated, discontinued or dose changed.

Lumefantrine: Additive QTc-prolongation may occur. Concomitant therapy should be avoided.

Vorinostat: Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Warfarin: Azithromycin may increase the anticoagulant effect of warfarin by increasing its serum concentration.

Ziprasidone: Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.

Zuclopenthixol: Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).