Company InfoNewsInvestor InformationResearchDevelopmentCareersBusiness DevelopmentResourcesDrugs databaseBack to the home pageSearch  
Drugs database
Drugs A-Z

Brands A-Z

Drugs by categories

Drugs by manufacturer

Drugs by packager

Antibiotics for sale

Online Viagra bestellen in Nederland

Home / Drugs / Starting with B / Baclofen

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
Lioresal Intrathecal
CategoriesMuscle Relaxants
Skeletal Muscle Relaxants
GABA Agonists
Muscle Relaxants, Central
ManufacturersMedtronic inc
Schwarz pharma inc
Actavis totowa llc
Caraco pharmaceutical laboratories ltd
Impax laboratories inc
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Lannett holdings inc
Matrix laboratories ltd
Mylan pharmaceuticals inc
Northstar healthcare holdings ltd
Teva pharmaceuticals usa inc
Usl pharma inc
Vintage pharmaceuticals inc
Watson laboratories inc
Novartis pharmaceuticals corp
PackagersActavis Group
Advanced Pharmaceutical Services Inc.
Aidarex Pharmacuticals LLC
Alphapharm Party Ltd.
Amerisource Health Services Corp.
Apotheca Inc.
A-S Medication Solutions LLC
Bryant Ranch Prepack
Caraco Pharmaceutical Labs
Cardinal Health
Caremark LLC
Comprehensive Consultant Services Inc.
Corepharma LLC
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Genpharm LP
Heartland Repack Services LLC
Innoviant Pharmacy Inc.
Ivax Pharmaceuticals
Keltman Pharmaceuticals Inc.
Lake Erie Medical and Surgical Supply
Lannett Co. Inc.
Major Pharmaceuticals
Mckesson Corp.
Medisca Inc.
Murfreesboro Pharmaceutical Nursing Supply
Northstar Rx LLC
Novartis AG
Nucare Pharmaceuticals Inc.
Palmetto Pharmaceuticals Inc.
PD-Rx Pharmaceuticals Inc.
Pharmaceutical Packaging Center
Physicians Total Care Inc.
Piramal Healthcare
Preferred Pharmaceuticals Inc.
Prepak Systems Inc.
Prescription Dispensing Service Inc.
Rebel Distributors Corp.
Remedy Repack
Resource Optimization and Innovation LLC
Sandhills Packaging Inc.
Southwood Pharmaceuticals
St Mary's Medical Park Pharmacy
Stat Rx Usa
UDL Laboratories
United Research Laboratories Inc.
USL Pharma Inc.
Vangard Labs Inc.
Vintage Pharmaceuticals Inc.
Watson Pharmaceuticals


For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.


Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

mechanism of action

Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.


LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)


~ 15% of the dose is metabolized in the liver, primarily by deamination. 70-80% of the dose is excreted unchanged or as metabolites in urine and the remainder is excreted in feces.


Rapidly and almost completely absorbed from the GI tract.

half life

2.5-4 hours

route of elimination

In a study using radiolabeled baclofen, approximately 85% of the dose was excreted unchanged in the urine and feces. Baclofen is excreted primarily by the kidney as unchanged drug; 70 - 80% of a dose appears in the urine as unchanged drug. The remainder is excreted as unchanged drug in the feces or as metabolites in the urine and feces.