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Home / Drugs / Starting with B / Benzatropine

Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson’s disease. It may also be used to treat extrapyramidal reactions, such as dystonia and Parkinsonism, caused by antipsychotics (e.g. phenothiazines). Symptoms of Parkinson’s disease and extrapyramidal reactions arise from decreases in dopaminergic activity which creates an imbalance between dopaminergic and cholinergic activity. Anticholinergic therapy is thought to aid in restoring this balance leading to relief of symptoms. In addition to its anticholinergic effects, benztropine also inhibits the reuptake of dopamine at nerve terminals via the dopamine transporter. Benzotropine also produces antagonistic effects at the histamine H1 receptor.
PMS Benztropine
CategoriesAntiparkinson Agents
Muscarinic Antagonists
ManufacturersHikma farmaceutica (portugal) sa
Nexus pharmaceuticals inc
Pharmaforce inc
Lundbeck inc
Actavis totowa llc
Corepharma llc
Invagen pharmaceuticals inc
Lannett holdings inc
Mutual pharmaceutical co inc
Pliva inc
Quantum pharmics ltd
Usl pharma inc
Vintage pharmaceuticals llc
Merck and co inc
PackagersAdvanced Pharmaceutical Services Inc.
Amerisource Health Services Corp.
Amneal Pharmaceuticals
AQ Pharmaceuticals Inc.
Cardinal Health
Comprehensive Consultant Services Inc.
Corepharma LLC
Coupler Enterprises Inc.
Dept Health Central Pharmacy
Direct Dispensing Inc.
Dispensing Solutions
Goldline Laboratories Inc.
Heartland Repack Services LLC
Hikma Pharmaceuticals
Ivax Pharmaceuticals
Liberty Pharmaceuticals
Lundbeck Inc.
Major Pharmaceuticals
Medisca Inc.
Merck & Co.
Murfreesboro Pharmaceutical Nursing Supply
Neuman Distributors Inc.
Nexus Pharmaceuticals
Nucare Pharmaceuticals Inc.
Pharmaceutical Packaging Center
Physicians Total Care Inc.
Pliva Inc.
Prepackage Specialists
Prepak Systems Inc.
Rebel Distributors Corp.
Remedy Repack
Rising Pharmaceuticals
Sandhills Packaging Inc.
Schein Pharmaceutical Inc.
Southwood Pharmaceuticals
Tya Pharmaceuticals
UDL Laboratories
United Research Laboratories Inc.
USL Pharma Inc.
Vangard Labs Inc.
Vintage Pharmaceuticals Inc.
West-Ward Pharmaceuticals
SynonymsBenzatropina [INN-Spanish]
Benzatropine mesilate
Benzatropinum [INN-Latin]
Benztropine Mesylate
Tropine Benzohydryl Ether


For use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs.


Benztropine is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug-induced extrapyramidal reactions (except tardive dyskinesia). Benztropine possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism. Benztropine's anticholinergic activity is about equal to that of atropine. Benztropine also inhibits dopamine reuptake via the dopamine transporter at nerve terminals.

mechanism of action

Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.


Signs of overdose include confusion, nervousness, listlessness, hallucinations, dizziness; muscle weakness, ataxia, dry mouth, mydriasis, blurred vision, palpitations, tachycardia, elevated blood pressure, nausea, vomiting, dysuria, numbness of fingers, headache, delirium, coma, shock, convulsions, respiratory arrest, anhidrosis, hyperthermia, glaucoma, and constipation.


Onset of action is 1-2 hours following oral administration. The onset of action is within minutes when administered by IM or IV injection.

drug interactions

Donepezil: Possible antagonism of action

Galantamine: Possible antagonism of action

Haloperidol: The anticholinergic increases the risk of psychosis and tardive dyskinesia

Rivastigmine: Possible antagonism of action

Tacrine: The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Benztropine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.

Trimethobenzamide: Trimethobenzamide and Benztropine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Triprolidine: Triprolidine and Benztropine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Trospium: Trospium and Benztropine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.