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Home / Drugs / Starting with B / Benzonatate

Benzonatate is a non-narcotic oral antitussive (cough suppressant) drug which works by anesthetizing the tissues of the lungs and pleura responsible for the cough reflex. It is chemically related to other ester anesthetics such as procaine. It has an anesthetic (numbing) action similar to that of benzocaine and "numbs" the stretch sensors in the lungs. It is the stretching of these sensors with breathing that causes the cough. It was approved by the FDA in 1958.
Tessalon Perles
ManufacturersBanner pharmacaps inc
Kv pharmaceutical co
Mikart inc
Orit laboratories llc
Sun pharmaceutical industries inc
The pharma network llc
Zydus pharmaceuticals usa inc
Forest laboratories inc
PackagersAccucaps Industries Ltd.
Advanced Pharmaceutical Services Inc.
Amerisource Health Services Corp.
Amneal Pharmaceuticals
Apotheca Inc.
A-S Medication Solutions LLC
Ascend Laboratories LLC
Atlantic Biologicals Corporation
Atley Pharmaceuticals
Banner Pharmacaps Inc.
Barr Pharmaceuticals
Bryant Ranch Prepack
Cadila Healthcare Ltd.
Caraco Pharmaceutical Labs
Cardinal Health
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Ethex Corp.
Forest Pharmaceuticals
H.J. Harkins Co. Inc.
Heartland Repack Services LLC
Inwood Labs
IVC Industries Inc.
Kaiser Foundation Hospital
KV Pharmaceutical Co.
Lake Erie Medical and Surgical Supply
Liberty Pharmaceuticals
Major Pharmaceuticals
Mallinckrodt Inc.
Murfreesboro Pharmaceutical Nursing Supply
Nucare Pharmaceuticals Inc.
Palmetto Pharmaceuticals Inc.
Patient First Corp.
PD-Rx Pharmaceuticals Inc.
Pharmaceutical Utilization Management Program VA Inc.
Pharmaceutics International Inc.
Physicians Total Care Inc.
Pliva Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prescript Pharmaceuticals
Provident Pharmaceuticals LLC
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Resource Optimization and Innovation LLC
Stat Rx Usa
Stat Scripts LLC
Swiss Caps Ag
United Research Laboratories Inc.
Vangard Labs Inc.
Zydus Pharmaceuticals
SynonymsBenzonatato [INN-Spanish]
Benzonatatum [INN-Latin]


For the symptomatic relief of cough. Has also been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules to provide oropharyngeal anesthesia for conscious intubation.


Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions. The drug acts peripherally by anesthetizing the stretch receptors located in the respiratory passages, lungs, and pleura through the dampening of their activity, which reduces the cough reflex.

mechanism of action

Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. Since these receptors are responsible for mediating the cough reflex, anesthetizing these receptors result in the inhibiton of cough production. Benzonatate also suppresses transmission of the cough reflex at the level of the medulla where the afferent impulse is transmitted to the motor nerves. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.


Restlessness, tremors, seizures and unconsciousness.


Benzonatate is hydrolyzed to para-aminobenzoic acid (PABA) by plasma esterases

half life

3-8 hours