indication

For treatment of severe infections caused by susceptible bacteria.

pharmacology

Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotiam works by inhibiting bacterial cell wall biosynthesis.

mechanism of action

The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

toxicity

Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.

absorption

Rapidly absorbed following intramuscular injection. Bioavailability is 60% following intramuscular injection.

half life

Approximately 1 hour.