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mechanism of actionCefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.
route of eliminationOver 90 percent of the drug is excreted unchanged in the urine within six hours.
drug interactionsAmikacin: Increased risk of nephrotoxicity
Gentamicin: Increased risk of nephrotoxicity
Netilmicin: Increased risk of nephrotoxicity
Probenecid: Probenecid may increase the serum level of cefradine.
Tobramycin: Increased risk of nephrotoxicity