indication

Used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.

pharmacology

Ceftibuten is a third-generation cephalosporin antibiotic.

mechanism of action

Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.

toxicity

Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.

biotransformation

A study with radiolabeled ceftibuten administered to 6 healthy adult male volunteers demonstrated that cis-ceftibuten is the predominant component in both plasma and urine. About 10% of ceftibuten is converted to the trans-isomer is approximately 1/8 as antimicrobially potent as the cis-isomer.

absorption

Rapidly absorbed following oral administration.

route of elimination

Ceftibuten is excreted in the urine; 95% of the administered radioactivity was recovered either in urine or feces.