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Home / Drugs / Starting with C / Cefuroxime

Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. [PubChem]
CategoriesAnti-Bacterial Agents
ManufacturersWarner chilcott inc
Hoffmann la roche inc
Ranbaxy laboratories ltd
Alkem laboratories ltd
Apotex inc etobicoke site
Aurobindo pharma ltd inc
Lupin ltd
Orchid healthcare
Sandoz inc
Teva pharmaceuticals usa inc
Wockhardt ltd
App pharmaceuticals llc
Hikma farmaceutica portugal lda
Marsam pharmaceuticals llc
Steri pharma llc
Acs dobfar spa
B braun medical inc
Samson medical technologies llc
Eli lilly and co
PackagersAidarex Pharmacuticals LLC
Amerisource Health Services Corp.
Apotex Inc.
APP Pharmaceuticals
A-S Medication Solutions LLC
Aurobindo Pharma Ltd.
B. Braun Melsungen AG
Baxter International Inc.
BMH Ltd.
Bristol-Myers Squibb Co.
Bryant Ranch Prepack
Cardinal Health
Cura Pharmaceutical Co. Inc.
DAVA Pharmaceuticals
Dispensing Solutions
Diversified Healthcare Services Inc.
Dorx LLC
Elan Pharmaceuticals Inc.
Eli Lilly & Co.
F Hoffmann-La Roche Ltd.
Forum Products Inc.
GC Hanford Manufacturing Co.
GlaxoSmithKline Inc.
Greenstone LLC
Hikma Pharmaceuticals
Hospira Inc.
Liberty Pharmaceuticals
Lupin Pharmaceuticals Inc.
Major Pharmaceuticals
Murfreesboro Pharmaceutical Nursing Supply
Northstar Rx LLC
Nucare Pharmaceuticals Inc.
Orchid Healthcare
PD-Rx Pharmaceuticals Inc.
Pharmaceutical Utilization Management Program VA Inc.
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prepak Systems Inc.
Prescript Pharmaceuticals
Ranbaxy Laboratories
Rebel Distributors Corp.
Resource Optimization and Innovation LLC
Sagent Pharmaceuticals
Samson Medical Technologies
Sandhills Packaging Inc.
Southwood Pharmaceuticals
Stat Rx Usa
Teva Pharmaceutical Industries Ltd.
UDL Laboratories
Watson Pharmaceuticals
West-Ward Pharmaceuticals
Wockhardt Ltd.
World Gen LLC
Zyber Pharmaceuticals
Cefuroxime [USAN:BAN:INN]
Cefuroximo [INN-Spanish]
Cefuroximum [INN-Latin]


For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.


Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Cefuroxime axetil is the prodrug

mechanism of action

Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.


Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.


The axetil moiety is metabolized to acetaldehyde and acetic acid.


Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).

half life

Approximately 80 minutes following intramuscular or intravenous injection.

drug interactions

Amikacin: Increased risk of nephrotoxicity

Gentamicin: Increased risk of nephrotoxicity

Netilmicin: Increased risk of nephrotoxicity

Probenecid: Probenecid may increase the serum level of cefuroxime.

Tobramycin: Increased risk of nephrotoxicity