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indicationFor treatment of infections caused by susceptible bacteria.
pharmacologyCephapirin is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms. Cephapirin is more resistant to beta-lactamases than are the penicillins and so is effective against staphylococci, with the exception of methicillin-resistant staphylococci.
mechanism of actionThe bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
toxicityRats exposed via the oral route to cephapirin displayed low acute toxicity (LD50 = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.
biotransformationMajor metabolite detected is desacetylcephapirin.
drug interactionsAmikacin: Increased risk of nephrotoxicity
Gentamicin: Increased risk of nephrotoxicity
Netilmicin: Increased risk of nephrotoxicity
Tobramycin: Increased risk of nephrotoxicity