indication

Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.

pharmacology

Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.

mechanism of action

The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.

toxicity

Symptoms of a chlorphenesin overdose include drowsiness and nausea.

biotransformation

Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.

absorption

Rapid and complete.

half life

2.3-5 hours