| A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223) |
| Brands | Apsedon
Clomina
Desopimon
Dezopimon
Effox
Lucofen
Lucofene
Nilgana
|
| Categories | Sympathomimetics
Appetite Depressants
|
| Manufacturers | Parke davis div warner lambert co
|
| Synonyms | 1-(4-Chlorophenyl)-2-methyl-2-propanamine
1-(p-Chlorophenyl)-2-methyl-2-aminopropane
1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride
4-Chloro-alpha,alpha-dimethylbenzeneethanamine
4-Chloro-alpha,alpha-dimethylphenethylamine
alpha,alpha-dimethyl-p-chlorophenethylamine
Beta-(p-chlorophenyl)-alpha,alpha-dimethylethylamine
Chlorophentermine
Chlorophentermine hydrochloride
Chlorpentermine
Chlorphenteramine
Chlorphentermine hydrochloride
Chlorphenterminum [inn-latin]
Chlorphenterminum hydrochloride
Clorfentermina [inn-spanish]
P-chloro-alpha,alpha-dimethylphenethylamine
P-chlorphentermine hydrochloride
|
indication
Used as an appetite suppressant.
pharmacology
Chlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
absorption
Well absorbed following oral administration.
half life
40 hours
