Cinnarizine | Genelabs.com

Cinnarizine is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.
Brands	Aplactan Aplexal Apotomin Artate Carecin Cerebolan Cinaperazine Cinazyn Cinnacet Cinnageron Cinnarizine Stugeron Corathiem Denapol Dimitron Dimitronal Eglen Folcodal Giganten Glanil Hilactan Ixertol Katoseran Labyrin Lazeta Marisan Midronal Mitronal Olamin Processine Sedatromin Sepan Siptazin Spaderizine Stugeron Stutgeron Stutgin Toliman
Categories	Calcium Channel Blockers Anti-Allergic Agents Histamine H1 Antagonists

indication

For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.

pharmacology

Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.

mechanism of action

Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.

Drugs database

	Drugs A-Z Brands A-Z Drugs by categories Drugs by manufacturer Drugs by packager Antibiotics for sale Online Viagra bestellen in Nederland