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indicationFor use with Amoxicillin, clavulanic acid is suitable for the treatment of infections with Staph. aureus and Bacteroides fragilis, or with beta-lactamase producing H. influenzae and E. coli.
pharmacologyClavulanic acid, produced by the fermentation of Streptomyces Clavuligerus, is a beta-lactam structurally related to the penicillins. Clavulanic acid is used in conjunction with amoxicillin for the treatment of bronchitis and urinary tract, skin, and soft tissue infections caused by beta-lactamase producing organisms.
mechanism of actionClavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases, commonly found in microorganisms resistant to penicillins and cephalosporins. Binding and irreversibly inhibiting the beta-lactamase results in a restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria. By inactivating beta-lactamase (the bacterial resistance protein), the accompanying penicillin/cephalosporin drugs may be made more potent as well.
toxicityGastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. Rash, hyperactivity, or drowsiness have also been observed in a small number of patients
half life1.0 hour
drug interactionsDemeclocycline: Possible antagonism of action
Doxycycline: Possible antagonism of action
Ethinyl Estradiol: This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol: This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline: Possible antagonism of action
Methotrexate: The penicillin increases the effect and toxicity of methotrexate
Minocycline: Possible antagonism of action
Oxytetracycline: Possible antagonism of action
Rolitetracycline: Possible antagonism of action
Tetracycline: Possible antagonism of action