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Cyclacillin |
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indicationFor the treatment of bacterial infections caused by susceptible organisms.pharmacologyCyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclacillin is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclacillin has been replaced by newer penicillin treatments.mechanism of actionThe bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclacillin is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.toxicitySymptoms of overdose include severe diarrhea, nausea and vomiting.absorptionModerately absorbed.drug interactionsDemeclocycline: Possible antagonism of actionDoxycycline: Possible antagonism of action Ethinyl Estradiol: This anti-infectious agent could decrease the effect of the oral contraceptive Minocycline: Possible antagonism of action Tetracycline: Possible antagonism of action |