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Home / Drugs / Starting with D / Drotaverine 		 
Drotaverine
  

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.
BrandsDrotin
No-Spa
Synonymsdrotaverin

indication

Used in the treatment of functional bowel disorders and alleviating pain in renal colic.

pharmacology

Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells.

mechanism of action

Drotaverine inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.

biotransformation

Hepatic

absorption

Bioavailability is highly variable

half life

7 to 12 hours

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