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Home / Drugs / Starting with F / Famotidine
 
Famotidine
 

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]
BrandsAmfamox
Antodine
Apo-Famotidine
Apogastine
Bestidine
Blocacid
Brolin
Cepal
Confobos
Cronol
Cuantin
Dibrit 40
Digervin
Dinul
Dipsin
Dispromil
Dispronil
Duovel
Durater
Evatin
Fadin
Fadine
Fadyn
Fagastine
Famo
Famocid
Famodar
Famodil
Famodin
Famodine
Famogard
Famonit
Famopsin
Famos
Famosan
Famotal
Famotep
Famotin
Famovane
Famowal
Famox
Famoxal
Famtac
Famulcer
Fanobel
Fanosin
Fanox
Farmotex
Ferotine
Fibonel
Fluxid
Fudone
Ganor
Gaster
Gastridan
Gastridin
Gastrion
Gastro
Gastrodomina
Gastrofam
Gastropen
Gastrosidin
H2 Bloc
Hacip
Huberdina
Ingastri
Invigan
Lecedil
Logos
Mensoma
Midefam
Mosul
Motiax
Muclox
Mylanta AR
Neocidine
Nevofam
Notidin
Novo-Famotidine
Nu-Famotidine
Nulceran
Nulcerin
Panalba
Pepcid
Pepcid AC
Pepcid RPD
Pepcidin
Pepcidin Rapitab
Pepcidina
Pepcidine
Pepdif
Pepdine
Pepdul
Pepfamin
Peptan
Peptidin
Peptifam
Pepzan
Purifam
Quamatel
Quamtel
Renapepsa
Restadin
Rogasti
Rubacina
Sedanium-R
Sigafam
Supertidine
Tairal
Tamin
Tipodex
Topcid
Ulcatif
Ulceprax
Ulcofam
Ulfagel
Ulfam
Ulfamid
Ulfinol
Ulgarine
Vagostal
Weimok
Whitidin
Yamarin
CategoriesAnti-Ulcer Agents
Histamine H2 Antagonists
ManufacturersLupin ltd
Navinta llc
Salix pharmaceuticals inc
Akorn strides llc
Apotex inc richmond hill
Apothecon inc div bristol myers squibb
App pharmaceuticals llc
Baxter healthcare corp anesthesia and critical care
Baxter healthcare corp
Bedford laboratories div ben venue laboratories inc
Hospira inc
Ben venue laboratories inc
Claris lifesciences ltd
Abbott laboratories
Baxter healthcare internati0nal specialty therapies div
Merck research laboratories div merck co inc
L perrigo co
Schwarz pharma inc
Actavis elizabeth llc
Alembic ltd
Apotex inc
Carlsbad technology inc
Dr reddys laboratories ltd
Genpharm inc
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Mutual pharmaceutical co inc
Mylan pharmaceuticals inc
Perrigo co
Ranbaxy laboratories inc
Sandoz inc
Teva pharmaceuticals usa inc
Watson laboratories inc
Wockhardt ltd
Wockhardt americas inc
PackagersAdvanced Pharmaceutical Services Inc.
Akorn Inc.
Amerisource Health Services Corp.
APP Pharmaceuticals
A-S Medication Solutions LLC
Atlantic Biologicals Corporation
Baxter International Inc.
Bedford Labs
Ben Venue Laboratories Inc.
Bryant Ranch Prepack
Cardinal Health
Carlsbad Technology Inc.
Chain Drug
Corepharma LLC
CVS Pharmacy
Dispensing Solutions
Diversified Healthcare Services Inc.
Doctor Reddys Laboratories Ltd.
H.J. Harkins Co. Inc.
Heartland Repack Services LLC
Hospira Inc.
Ivax Pharmaceuticals
Johnson & Johnson Healthcare
Kaiser Foundation Hospital
Lake Erie Medical and Surgical Supply
Legacy Pharmaceuticals Packaging LLC
Lupin Pharmaceuticals Inc.
Major Pharmaceuticals
Mckesson Corp.
Medisca Inc.
Merck & Co.
Murfreesboro Pharmaceutical Nursing Supply
Mylan
Northstar Rx LLC
Nucare Pharmaceuticals Inc.
PCA LLC
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pharmaceutical Utilization Management Program VA Inc.
Pharmedium
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Salix Pharmaceuticals
Sandhills Packaging Inc.
Southwood Pharmaceuticals
Strides Arcolab Limited
Teva Pharmaceutical Industries Ltd.
UDL Laboratories
Vangard Labs Inc.
Walgreen Co.
Watson Pharmaceuticals
Wockhardt Ltd.
Yung Shin Pharmaceutical Industry Ltd.
Zydus Pharmaceuticals
SynonymsFamotidina [Spanish]
Famotidinum [Latin]

indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

pharmacology

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

mechanism of action

Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

toxicity

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

biotransformation

Hepatic.

absorption

The bioavailability of oral doses is 40-45%.

half life

2.5-3.5 hours

route of elimination

Renal clearance is 250-450 mL/min, indicating some tubular excretion.

drug interactions

Atazanavir: This gastric pH modifier decreases the levels/effects of atazanavir

Cefditoren: H2-Antagonists such as famotidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.

Enoxacin: Famotidine may decrease the absorption of enoxacin.

Itraconazole: The H2-receptor antagonist, famotidine, may decrease the absorption of itraconazole.

Ketoconazole: The H2-receptor antagonist, famotidine, may decrease the absorption of ketoconazole.