indication

Used for the short-term treatment of anxiety disorders.

pharmacology

Fludiazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Fludiazepam accumulates primarily in the cortex and thalamus.

mechanism of action

Fludiazepam has similar action to diazepam, but binds with four times more affinity to benzodiazepine receptors than diazepam.

toxicity

Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.

biotransformation

Hepatic.