Flunarizine | Genelabs.com

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Brands	Apo-flunarizine capsules Flufenal Fluvert Issium Novo-Flunarizine Sibelium Vertix Zinasen
Categories	Anticonvulsants Vasodilator Agents Calcium Channel Blockers Histamine H1 Antagonists
Synonyms	(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine Flunarizina [inn-spanish] flunarizine dihydrochloride Flunarizine Hydrochloride Flunarizinum [inn-latin]

indication

Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

pharmacology

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.

mechanism of action

Flunarizine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

biotransformation

Hepatic, to two metabolites via N-dealylation and hydroxylation.

absorption

85% following oral administration.

half life

18 days

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