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Home / Drugs / Starting with F / Follitropin beta 		 
Follitropin beta
  

Human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids.
BrandsFollistim (Organon)
Gonal F
Gonal-F
CategoriesFertility Agents
ManufacturersOrganon usa inc
Emd serono inc
PackagersEMD Canada Inc.
Organon Pharmaceuticals
Vetter Pharma Fertigung GmbH and Co. KG
SynonymsFollicle-stimulating hormone beta subunit
Follitropin alfa/beta
Follitropin beta chain precursor
FSH-B
FSH-beta

indication

For treatment of female infertility

pharmacology

Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development.

mechanism of action

Follitropin alpha is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.

half life

2-5 hrs

Terms of Use