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Home / Drugs / Starting with g / gamma-Homolinolenic acid
gamma-Homolinolenic acid

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. [PubChem]
BrandsStar GLA (GNC)
Tona-lean 1000 CLA (Action Labs)
CategoriesDietary supplement
Synonyms(8E,11E,14E)-8,11,14-Icosatrienoic acid
(Z,Z,Z)-8,11,14-Eicosatrienoic acid
8,11,14-Eicosatrienoic Acid
cis-8,11,14-Eicosatrienoic acid
Dihomo-gamma-linolenic acid
Homo-gamma-linolenic acid


For nutritional supplementation, also for treating dietary shortage or imbalance


Dihomo gamma-linolenic acid or DHLA is an n-6 (omega-6) polyunsaturated fatty acid. It is comprised of 20 carbon atoms and three double bonds. DHLA is a byproduct of the 18 carbon gamma-linolenic acid (GLA). DHLA is then converted into prostaglandin E1 (PGE1). PGE1 inhibits platelet aggregation and also exerts a vasodilatory effect.

mechanism of action

DHLA (or DGLA) is a precursor in the synthesis of prostaglandin E1 (PGE1) as well as the series-3 prostaglandins. It also serves as a precursor in the synthesis of eicosapentaenoic acid (EPA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-thrombogenic, anti-inflammatory and anti-atherogenic properties. PGE1 inhibits platelet aggregation and has a vasodilation action. DHLA has also been shown to reduce the production/activity of tumor necrosis factor alpha.