mechanism of action

Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use. In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans. Since glucosamine is classified as a dietary supplement, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.

drug interactions

Chlorpropamide: Possible hyperglycemia

Gliclazide: Possible hyperglycemia

Glimepiride: Possible hyperglycemia

Glyburide: Possible hyperglycemia

Metformin: Possible hyperglycemia

Miglitol: Possible hyperglycemia

Nateglinide: Possible hyperglycemia

Pioglitazone: Possibly hyperglycemia

Repaglinide: Possible hyperglycemia