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Home / Drugs / Starting with I / Ibritumomab 		 
Ibritumomab
  

Indium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each.
BrandsZevalin (IDEC Pharmaceuticals)
CategoriesAntineoplastic Agents
PackagersS
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SynonymsIg gamma-2A chain C region, membrane-bound form
radiolabeled murine anti-CD20

indication

For treatment of non-Hodgkin's lymphoma

pharmacology

Ibritumomab is a murine monoclonal antibody against CD20 that has been radiolabeled with yttrium-90.

mechanism of action

The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.

biotransformation

Most likely removed by opsonization via the reticuloendothelial system when bound to B cells, or by human antimurine antibody production

half life

0.8 hours (mammalian reticulocytes, in vitro)

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