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Home / Drugs / Starting with M / Metaxalone

Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin®) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin comes in an 800 mg scored tablet. It previously came in both 400 mg and 800 mg tablets. The 400 mg tablet has been discontinued. Possible side effects include nausea, vomiting, drowsiness and CNS side effects such as dizziness, headache, and irritability.
CategoriesHypnotics and Sedatives
Muscle Relaxants, skeletal muscle
ManufacturersSandoz inc
King pharmaceuticals inc
Elan Corporation
PackagersAmerisource Health Services Corp.
Apotheca Inc.
A-S Medication Solutions LLC
Blenheim Pharmacal
Cardinal Health
D.M. Graham Laboratories Inc.
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Eon Labs
H.J. Harkins Co. Inc.
Innoviant Pharmacy Inc.
Keltman Pharmaceuticals Inc.
King Pharmaceuticals Inc.
Lake Erie Medical and Surgical Supply
Liberty Pharmaceuticals
Mckesson Corp.
Nucare Pharmaceuticals Inc.
Par Pharmaceuticals
PD-Rx Pharmaceuticals Inc.
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prescript Pharmaceuticals
Rebel Distributors Corp.
Redpharm Drug
Resource Optimization and Innovation LLC
Southwood Pharmaceuticals
St Mary's Medical Park Pharmacy
Stat Rx Usa
West-Ward Pharmaceuticals
SynonymsMetassalone [Dcit]
Metaxalona [INN-Spanish]
Metaxalonum [INN-Latin]
Metaxalonum [Latin]


For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.


Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.

mechanism of action

The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.


LD50=775mg/kg (Rat, oral); LD50=1690 mg/kg (Mouse, oral). When determining the LD50 in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes.


Probably hepatic.


The absolute bioavailability of metaxalone from Skelaxin tablets is not known.

half life

9.2 (+/- 4.8) hours

route of elimination

Metaxalone is metabolized by the liver and excreted in the urine as unidentified metabolites.