indication

Indicated for the treatment and management of hypotension.

pharmacology

Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

mechanism of action

Methoxamine acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic and diastolic).

drug interactions

Amitriptyline: The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of methoxamine.

Amoxapine: The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of methoxamine.

Clomipramine: The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of methoxamine.

Desipramine: The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of methoxamine.

Doxepin: The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of methoxamine.

Guanethidine: Methoxamine may decrease the effect of guanethidine.

Imipramine: The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of methoxamine.

Isocarboxazid: Increased arterial pressure

Linezolid: Possible increase of arterial pressure

Methyldopa: Increased arterial pressure

Midodrine: Increased arterial pressure

Moclobemide: Moclobemide increases the sympathomimetic effect of methoxamine.

Nortriptyline: The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of methoxamine.

Phenelzine: Increased arterial pressure

Rasagiline: Increased arterial pressure

Reserpine: Increased arterial pressure

Tranylcypromine: The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the alpha1-agonist, Methoxamine. Concomitant therapy should be avoided.

Trimipramine: Trimipramine may increase the vasopressor effect of the alpha1-agonist, Methoxamine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.