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Home / Drugs / Starting with N / Naproxen

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. [PubChem]
DL Naproxen
Naproxen Sodium
CategoriesCyclooxygenase Inhibitors
Gout Suppressants
ManufacturersRoche palo alto llc
Roxane laboratories inc
Actavis elizabeth llc
Alphapharm party ltd
Pliva inc
Sandoz inc
Teva pharmaceuticals usa inc
Amneal pharmaceuticals ny llc
Baxter healthcare corp anesthesia and critical care
Dava pharmaceuticals inc
Glenmark generics ltd
Hamilton pharmaceuticals ltd
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Mylan pharmaceuticals inc
Perrigo r and d co
Purepac pharmaceutical co
Teva pharmaceuticals usa
Watson laboratories inc
Westward pharmaceutical corp
Zydus pharmaceuticals usa inc
Banner pharmacaps inc
Stat trade inc
Watson laboratories inc florida
Bayer healthcare llc
Able laboratories inc
Contract pharmacal corp
Dr reddys laboratories inc
Dr reddys laboratories ltd
Hikma pharmaceuticals
L perrigo co
PackagersAdvanced Pharmaceutical Services Inc.
Aidarex Pharmacuticals LLC
Altura Pharmaceuticals Inc.
Amerisource Health Services Corp.
Amneal Pharmaceuticals
Apotheca Inc.
Apothecary Shop Wholesale
A-S Medication Solutions LLC
AstraZeneca Inc.
Atlantic Biologicals Corporation
Avkare Incorporated
Bayer Healthcare
Blenheim Pharmacal
Bryant Ranch Prepack
Cardinal Health
Chain Drug
Comprehensive Consultant Services Inc.
Corepharma LLC
Coupler Enterprises Inc.
CVS Pharmacy
DAVA Pharmaceuticals
Dept Health Central Pharmacy
DHHS Program Support Center Supply Service Center
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Doctor Reddys Laboratories Ltd.
Elan Pharmaceuticals Inc.
Ethex Corp.
F Hoffmann-La Roche Ltd.
Glenmark Generics Ltd.
Golden State Medical Supply Inc.
Group Health Cooperative
H.J. Harkins Co. Inc.
Heartland Repack Services LLC
Hikma Pharmaceuticals
Innovative Manufacturing and Distribution Services Inc.
Innoviant Pharmacy Inc.
International Ethical Labs Inc.
Ivax Pharmaceuticals
Kaiser Foundation Hospital
Keltman Pharmaceuticals Inc.
Lake Erie Medical and Surgical Supply
Legacy Pharmaceuticals Packaging LLC
Liberty Pharmaceuticals
Major Pharmaceuticals
Medique Products
Medisca Inc.
Medvantx Inc.
Murfreesboro Pharmaceutical Nursing Supply
Novopharm Ltd.
Nucare Pharmaceuticals Inc.
Palmetto Pharmaceuticals Inc.
Patheon Inc.
Patient First Corp.
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pharmaceutical Utilization Management Program VA Inc.
Pharmpak Inc.
Physician Partners Ltd.
Physicians Total Care Inc.
Pliva Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Prescription Dispensing Service Inc.
Quality Pharmaceuticals Services Inc.
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Resource Optimization and Innovation LLC
Roxane Labs
Sandhills Packaging Inc.
Southwood Pharmaceuticals
St Mary's Medical Park Pharmacy
Stat Rx Usa
Talbert Medical Management Corp.
Teva Pharmaceutical Industries Ltd.
Tya Pharmaceuticals
UDL Laboratories
Va Cmop Dallas
Vangard Labs Inc.
Victory Pharma
Walgreen Co.
Watson Pharmaceuticals
West-Ward Pharmaceuticals


For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.


Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties. As with other NSAIDs, its mode of action is not fully understood; however, its ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.

mechanism of action

The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.


ORAL (LD50): Acute: 248 mg/kg [Rat]. 360 mg/kg [Mouse]. Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.


Naproxen is extensively metabolized to 6-0-desmethyl naproxen and both parent and metabolites do not induce metabolizing enzymes.


Naproxen itself is rapidly and completely absorbed from the GI tract with an in vivo bioavailability of 95%. Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed resulting in higher peak plasma levels for a given dose. Food causes a slight decrease in the rate absorption.

half life

The observed terminal elimination half-life is approximately 15 hours.

drug interactions

Acenocoumarol: The NSAID, naproxen, may increase the anticoagulant effect of acenocoumarol.

Alendronate: Increased risk of gastric toxicity

Anisindione: The NSAID, naproxen, may increase the anticoagulant effect of anisindione.

Colesevelam: Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.

Cyclosporine: Monitor for nephrotoxicity

Dicumarol: The NSAID, naproxen, may increase the anticoagulant effect of dicumarol.

Ginkgo biloba: Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.

Lithium: The NSAID, naproxen, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.

Methotrexate: The NSAID, naproxen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.

Telmisartan: Concomitant use of Telmisartan and Naproxen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.

Timolol: The NSAID, Naproxen, may antagonize the antihypertensive effect of Timolol.

Trandolapril: The NSAID, Naproxen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Naproxen is initiated, discontinued or dose changed.

Treprostinil: The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Naproxen. Monitor for increased bleeding during concomitant thearpy.

Triflusal: The metabolite of triflusal, 2-hydroxy-4-trifluoro-methyl-benzoic acid (HTB), impairs the serum protein binding of naproxen to the same extent as acetylsalisylic acid. Thus, the free fraction of glisentide may be increased. A dosage reduction may be required if used in combination.

Vilazodone: Increased risk of bleeding with concomitant use of NSAIDs with vilazodone.

Warfarin: The antiplatelet effects of naproxen may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.