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Home / Drugs / Starting with N / Nystatin

Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.
BrandsBarstatin 100
Mytrex F
nystatin dihydrate
Nystatin-Triamcinolone Acetonide
PMS Nystatin
CategoriesAnti-Bacterial Agents
Antifungal Agents
ManufacturersBayer pharmaceuticals corp
Bristol myers squibb co
Alpharma us pharmaceuticals division
Lederle laboratories div american cyanamid co
Actavis mid atlantic llc
Altana inc
Perrigo new york inc
Taro pharmaceuticals usa inc
Teva pharmaceuticals usa inc
Vintage pharmaceuticals llc
Westwood squibb pharmaceuticals inc
Bristol myers squibb
Barlan pharmacal co inc
Dava pharmaceuticals inc
Paddock laboratories inc
Coastal pharmaceuticals inc
Kv pharmaceutical co
Par pharmaceutical inc
Upsher smith laboratories inc
X gen pharmaceuticals inc
Warner chilcott co llc
Apothecon inc div bristol myers squibb
Glenmark generics inc usa
Bausch and lomb pharmaceuticals inc
E fougera div altana inc
Morton grove pharmaceuticals inc
Pharmaderm div altana inc
Pharmafair inc
Roxane laboratories inc
Vintage pharmaceuticals inc
Vistapharm inc
Wockhardt eu operations (swiss) ag
Savage laboratories inc div altana inc
Mutual pharmaceutical co inc
Quantum pharmics ltd
Sandoz inc
Usl pharma inc
Watson laboratories inc
Holland rantos co inc
Odyssey pharmaceuticals inc
PackagersActavis Group
Advanced Pharmaceutical Services Inc.
Aidarex Pharmacuticals LLC
A-S Medication Solutions LLC
Atlantic Biologicals Corporation
Bausch & Lomb Inc.
Bryant Ranch Prepack
Cardinal Health
Contract Pharm
Cutis Pharma Inc.
Dept Health Central Pharmacy
Dispensing Solutions
Diversified Healthcare Services Inc.
E. Fougera and Co.
E.R. Squibb and Sons LLC
Glenmark Generics Ltd.
Major Pharmaceuticals
Medisca Inc.
Metrics Inc.
Midlothian Labs
Murfreesboro Pharmaceutical Nursing Supply
Mutual Pharmaceutical Co.
Novopharm Ltd.
Nycomed Inc.
Odyssey Pharmaceuticals Inc.
Paddock Labs
Palmetto Pharmaceuticals Inc.
Par Pharmaceuticals
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pharmaceutical Association
Pharmaceutics International Inc.
Physicians Total Care Inc.
Pliva Inc.
Precision Dose Inc.
Preferred Pharmaceuticals Inc.
Rebel Distributors Corp.
Savage Labs
Stat Scripts LLC
Taro Pharmaceuticals USA
Teva Pharmaceutical Industries Ltd.
USL Pharma Inc.
Vintage Pharmaceuticals Inc.
Vistapharm Inc.
Wockhardt Ltd.
Xactdose Inc.
X-Gen Pharmaceuticals


For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species


Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.

mechanism of action

Nystatin exerts its antifungal activity by binding to ergosterol found in fungal cell membranes. Binding to ergosterol causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death.


Nystatin is not absorbed from intact skin or mucous membrane.