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Oxacillin |
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indicationUsed in the treatment of resistant staphylococci infections.pharmacologyOxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Oxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Oxacillin results from the inhibition of cell wall synthesis and is mediated through Oxacillin binding to penicillin binding proteins (PBPs). Oxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.mechanism of actionBy binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor.half life20 to 30 minutesroute of eliminationOxacillin Sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.drug interactionsDemeclocycline: Possible antagonism of actionDoxycycline: Possible antagonism of action Ethinyl Estradiol: This anti-infectious agent could decrease the effect of the oral contraceptive Minocycline: Possible antagonism of action Tetracycline: Possible antagonism of action |