indication

Use to promote weight gain after weight loss following extensive surgery.

pharmacology

Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone.

mechanism of action

Oxandrolones interact with androgen receptors in target tissues.

toxicity

The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg.

biotransformation

Renal

half life

0.55 hours (1st phage), 9 hours (2nd phase)