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Home / Drugs / Starting with P / Pegademase bovine
Pegademase bovine

Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life
BrandsAdagen (Enzon Inc.)
CategoriesEnzyme Replacement Agents
ManufacturersSigma tau pharmaceuticals inc
PackagersBen Venue Laboratories Inc.
Enzon Inc.
SynonymsAdenosine aminohydrolase
Adenosine deaminase


For treatment of adenosine deaminase deficiency


Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adenosine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.

mechanism of action

Pegademase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.