For the treatment of infestation with Sarcoptes scabiei
Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
mechanism of action
Permethrin acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.
Oral, rat LD50
: 430 - 4000 mg/kg; skin, rabbit LD50
: 2000 mg/kg.
Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
Poorly absorbed through the skin.
route of elimination
Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.