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Home / Drugs / Starting with P / Pipobroman

An antineoplastic agent that acts by alkylation. [PubChem]
CategoriesAntineoplastic Agents
Antineoplastic Agents, Alkylating
ManufacturersAbbott laboratories pharmaceutical products div


For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.


Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.

mechanism of action

The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.


Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.


Well absorbed from the GI tract.

drug interactions

Acebutolol: Antagonism

Atenolol: Antagonism

Betaxolol: Antagonism

Bevantolol: Antagonism

Bisoprolol: Antagonism

Carteolol: Antagonism

Carvedilol: Antagonism

Esmolol: Antagonism

Labetalol: Antagonism

Metoprolol: Antagonism

Nadolol: Antagonism

Oxprenolol: Antagonism

Penbutolol: Antagonism

Pindolol: Antagonism

Practolol: Antagonism

Propranolol: Antagonism

Sotalol: Antagonism

Timolol: Antagonism