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indicationFor the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
pharmacologyPipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
mechanism of actionThe mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
toxicitySymptoms of overdose include hematologic toxicity, especially with chronic overdosage.
absorptionWell absorbed from the GI tract.
drug interactionsAcebutolol: Antagonism