indication

Used to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever.

pharmacology

Pivmecillinam is a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.

mechanism of action

Pivmecillinam interferes with the biosynthesis of the bacterial cell wall however its activity is slightly different from that of other penicillins and cephalosporins

absorption

Well absorbed following oral administration.

drug interactions

Demeclocycline: Possible antagonism of action

Doxycycline: Possible antagonism of action

Methacycline: Possible antagonism of action

Minocycline: Possible antagonism of action

Oxytetracycline: Possible antagonism of action

Rolitetracycline: Possible antagonism of action

Tetracycline: Possible antagonism of action