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Home / Drugs / Starting with P / Podofilox

A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem]
Podophyllotoxin 7
CategoriesKeratolytic Agents
Antineoplastic Agents, Phytogenic
Antimitotic agent
Tubulin Modulators
ManufacturersWatson pharmaceuticals inc
Collegium pharmaceutical inc
Paddock laboratories inc
PackagersDPT Laboratories Ltd.
Oclassen Pharmaceuticals Inc.
Paddock Labs
Physicians Total Care Inc.
Watson Pharmaceuticals
SynonymsPodophyllinic acid lactone


For treatment of external genital warts (Condyloma acuminatum).


Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas.

mechanism of action

The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication


Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.

half life

1.0 to 4.5 hours.