indication

Indicated for the treatment of epilepsy.

pharmacology

Progabide, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy.

mechanism of action

Progabide binds to both GABA_A and GABA_B receptors located on the terminals of primary afferent fibers. Binding to GABA_A results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABA_B receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters.

biotransformation

Hepatic

absorption

Well absorbed with a bioavailability of 60%

half life

4 hours