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Home / Drugs / Starting with R / Rasburicase

Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.
Elitek (Sanofi-Synthelabo Inc)
CategoriesAntihyperuricemic Agents
PackagersGlaxoSmithKline Inc.
Sanofi-Aventis Inc.
SynonymsUrate oxidase


For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)


Drugs used to treat lympohoid leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia often lead to the accumulation of toxic plasma levels of purine metabolites (i.e. uric acid). The injection of rasburicase reduces levels of uric acid and mitigates the toxic effects of chemotherapy induced tumor lysis.

mechanism of action

Rasburicase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).

half life

18 hours