A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. [PubChem] |
Categories | Anti-Bacterial Agents Aminoglycosides Antibacterial Agents
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Synonyms | 5-Amino-2-Aminomethyl-6-[4,6-Diamino-2-(3,4-Dihydroxy-5-Hydroxymethyl-Tetrahydro-Furan-2-Yloxy)-3-Hydroxy-Cyclohexyloxy]-Tetrahydro-Pyran-3,4-Diol Antibiotic SF 733 Ribastamin RIO SF-733 Vistamycin Xylostacin Xylostasin
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mechanism of action
Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. However, their exact mechanism of action is not fully known.