Company InfoNewsInvestor InformationResearchDevelopmentCareersBusiness DevelopmentResourcesDrugs databaseBack to the home pageSearch  
Drugs database
Drugs A-Z

Brands A-Z

Drugs by categories

Drugs by manufacturer

Drugs by packager

Antibiotics for sale

Online Viagra bestellen in Nederland

Home / Drugs / Starting with R / Rolitetracycline

A pyrrolidinylmethyl tetracycline. [PubChem]
CategoriesAnti-Bacterial Agents


Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.

mechanism of action

Rolitetracycline is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.


Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).

drug interactions

Acitretin: Increased risk of intracranial hypertension

Amoxicillin: Possible antagonism of action

Ampicillin: Possible antagonism of action

Carbenicillin: Possible antagonism of action

Clavulanate: Possible antagonism of action

Cloxacillin: Possible antagonism of action

Dicloxacillin: Possible antagonism of action

Ethinyl Estradiol: This anti-infectious agent could decrease the effect of the oral contraceptive

Etretinate: Increased risk of intracranial hypertension

Flucloxacillin: Possible antagonism of action

Isotretinoin: Increased risk of intracranial hypertension

Penicillin G: Possible antagonism of action

Penicillin V: Possible antagonism of action

Piperacillin: Possible antagonism of action

Pivampicillin: Possible antagonism of action

Pivmecillinam: Possible antagonism of action