Company InfoNewsInvestor InformationResearchDevelopmentCareersBusiness DevelopmentResourcesDrugs databaseBack to the home pageSearch  
Drugs database
Drugs A-Z

Brands A-Z

Drugs by categories

Drugs by manufacturer

Drugs by packager

Antibiotics for sale

Online Viagra bestellen in Nederland

Home / Drugs / Starting with S / Salicyclic acid
Salicyclic acid

A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
BrandsAdvanced pain relief callus removers
Advanced pain relief corn removers
Clear away wart remover
Compound W
Dr. Scholl's Callus Removers
Dr. Scholl's Corn Removers
Dr. Scholl's Wart Remover Kit
Duofil Wart Remover
Kyselina 2-hydroxybenzoova
Kyselina salicylova
Retarder SAX
Retarder W
Salicylic acid collodion
Salicylic acid soap
CategoriesAnti-Infective Agents
Keratolytic Agents
Antifungal Agents
Packagers7 Oaks Pharmaceutical Corp.
Aeropak (Uk)
Auriga Pharmaceuticals LLC
Avidas Pharmaceuticals
Breckenridge Pharmaceuticals
Collegium Pharmaceutical Inc.
Contract Pharm
Coria Laboratories
Direct Dispensing Inc.
DPT Laboratories Ltd.
Elorac Inc.
EMS Acquisition Corp.
Groupe Parima Inc.
Harmony Laboratories Inc.
Hi Tech Pharmacal Co. Inc.
JSJ Pharmaceuticals Inc.
Kaiser Foundation Hospital
Kamins Dermatologics Inc.
Major Pharmaceuticals
Medtech Labs
Murfreesboro Pharmaceutical Nursing Supply
Nucare Pharmaceuticals Inc.
Onset Therapeutics LLC
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Physicians Total Care Inc.
Pliva Inc.
Prasco Labs
PruGen Inc. Pharmaceuticals
River's Edge Pharmaceuticals
Seton Pharmaceuticals LLC
Sheffield Laboratories Div Faria Limited LLC
Sonar Products Inc.
Southwood Pharmaceuticals
Span Packaging Services LLC
Stiefel Labs
Summers Labs
Valeant Ltd.
2-Hydroxybenzenecarboxylic acid
2-Hydroxybenzoic acid
Acido salicilico
O-hydroxybenzoic acid
Orthohydroxybenzoic acid
Phenol-2-carboxylic acid
Salicylic acid


Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.


Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.

mechanism of action

Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis.


Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.