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Home / Drugs / Starting with S / Sargramostim

Human, recombinant GM-CSF, expressed in yeast. Glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Leucomax (Novartis)
Leukine (Berlex Laboratories Inc)
CategoriesAntineoplastic Agents
Immunomodulatory Agents
Anti-Infective Agents
PackagersBayer Healthcare
Genzyme Inc.
Hospira Inc.
Physicians Total Care Inc.
Wyeth Pharmaceuticals
SynonymsColony-stimulating factor
Granulocyte-macrophage colony-stimulating factor precursor


For the treatment of cancer and bone marrow transplant


Sargramostim is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.

mechanism of action

Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils