|Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors.
|Synonyms||Indium (111In) satumomab pendetide
Indium-111 satumomab pendetide
For diagnosis of extrahepatic malignant cancers
Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors.
mechanism of action
Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production
0.8 hours (mammalian reticulocytes, in vitro)