Company InfoNewsInvestor InformationResearchDevelopmentCareersBusiness DevelopmentResourcesDrugs databaseBack to the home pageSearch  
Drugs database
Drugs A-Z

Brands A-Z

Drugs by categories

Drugs by manufacturer

Drugs by packager

Antibiotics for sale

Online Viagra bestellen in Nederland

Home / Drugs / Starting with S / Scopolamine

An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Scopolamine and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic. [PubChem]
Adjuvants, Anesthesia
Muscarinic Antagonists
Cholinergic Antagonists
ManufacturersBoca pharmacal inc
Private formulations inc
PackagersA. Aarons Inc.
Adamis Laboratories
Advanced Pharmaceutical Services Inc.
Alcon Laboratories
Alza Corp.
Apace Packaging
Apotheca Inc.
APP Pharmaceuticals
Aristos Pharmaceuticals
A-S Medication Solutions LLC
Atlantic Biologicals Corporation
Auriga Pharmaceuticals LLC
Bausch & Lomb Inc.
Baxter International Inc.
Boca Pharmacal
Bradley Pharmaceuticals Inc.
Breckenridge Pharmaceuticals
Bryant Ranch Prepack
Burel Pharmaceuticals Inc.
C.O. Truxton Inc.
Carwin Associates Inc.
Central Texas Community Health Centers
Contract Pharm
Cornerstone Pharmacy
Corvit Pharmaceuticals
Dexo LLC
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Excellium Pharmaceutical Inc.
H.J. Harkins Co. Inc.
Hawthorn Pharmaceuticals
Hope Pharmaceuticals
Irisys Inc.
Kaiser Foundation Hospital
Kenwood Labs
Kraft Pharmaceutical Co. Inc.
Kylemore Pharmaceuticals
Larken Laboratories Inc.
Liberty Pharmaceuticals
Llorens Pharmaceutical
Magna Pharmaceuticals
Major Pharmaceuticals
Mckesson Corp.
Medi Rx Pharmaceutical Inc.
Mikart Inc.
Murfreesboro Pharmaceutical Nursing Supply
Nexgen Pharma Inc.
Novartis AG
Nucare Pharmaceuticals Inc.
Patient First Corp.
PBM Pharmaceuticals Inc.
PD-Rx Pharmaceuticals Inc.
Pharmaceutical Utilization Management Program VA Inc.
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Provident Pharmaceuticals LLC
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
River's Edge Pharmaceuticals
Sandhills Packaging Inc.
SJ Pharmaceuticals LLC
Southwood Pharmaceuticals
Sovereign Pharmaceuticals Ltd.
Trigen Laboratories Inc.
United Research Laboratories Inc.
Veratex Corp.
Vintage Pharmaceuticals Inc.
Vision Pharma LLC
West-Ward Pharmaceuticals
scopine (−)-tropate


For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.


Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Scopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Scopolamine also may work directly on the vomiting center. Scopolamine must be taken before the onset of motion sickness to be effective.

mechanism of action

Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).


Bioavailability is 10 - 50%

half life

4.5 hours

route of elimination

Less than 10% of the total dose is excreted in the urine as parent and metabolites over 108 hours.

drug interactions

Cinitapride: Anticholinergic agents like scopolamine may reduce the action of cinitapride.

Donepezil: Possible antagonism of action

Galantamine: Possible antagonism of action

Haloperidol: The anticholinergic increases the risk of psychosis and tardive dyskinesia

Tacrine: The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Scopolamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.

Trimethobenzamide: Trimethobenzamide and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Triprolidine: Triprolidine and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.

Trospium: Trospium and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.