A diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following intravenous injection, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times |
Brands | Megatope (IsoTex Diagnostics)
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Categories | Imaging Agents
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Manufacturers | Iso tex diagnostics inc Bayer pharmaceuticals corp Mallinckrodt medical inc
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Synonyms | Serum albumin precursor
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indication
For determination of total blood and plasma volumes
pharmacology
Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
mechanism of action
Serum albumin acts as a high molecular weight, very soluble osmolyte