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Home / Drugs / Starting with S / Sodium Tetradecyl Sulfate
Sodium Tetradecyl Sulfate

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Texapon K 14
CategoriesSurface-Active Agents
Sclerosing Agents
ManufacturersBioniche pharma usa llc
Elkins sinn div ah robins co inc
Bioniche Pharma
SynonymsMonotetradecylsulfate sodium salt
Sodium myristyl sulfate
Tetradecyl hydrogen sulphate
Tetradecyl sodium sulfate
Tetradecyl sulfate
Tetradecyl sulfuric Acid


For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.


Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

mechanism of action

Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.


LD50=1250 mg/kg (Orally in rat); LD50=3 ml/kg (Skin in rat)