drug interactions

Alprazolam: St. John's Wort may decrease the effect of the benzodiazepine, alprazolam.

Aminophylline: St. John's Wort decreases the effect of theophylline

Amprenavir: St. John's Wort decreases the effect of indinavir

Atazanavir: St. John's Wort decreases the levels/effects of atazanavir

Citalopram: St. John's Wort increases the effect and toxicity of the SSRI, citalopram.

Clonazepam: St. John's Wort may decrease the effect of the benzodiazepine, clonazepam.

Cyclosporine: St. John's Wort decreases the effect of cyclosporine

Delavirdine: St. John's Wort decreases the antiretroviral effect

Desvenlafaxine: Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.

Diazepam: St. John's Wort may decrease the effect of the benzodiazepine, diazepam.

Digoxin: St. John's Wort decreases the effect of digoxin

Efavirenz: St. John's Wort decreases the antiretroviral effect

Erlotinib: Decreased levels/effect of erlotinib

Escitalopram: St. John's Wort increases the effect and toxicity of the SSRI, escitalopram.

Ethinyl Estradiol: St. John's Wort could reduce the contraceptive effect

Fluoxetine: St. John's Wort increases the effect and toxicity of the SSRI, fluoxetine.

Fluvoxamine: St. John's Wort increases the effect and toxicity of the SSRI, fluvoxamine.

Fosamprenavir: St. John's Wort decreases the effect of indinavir

Gefitinib: The CYP3A4 inducer, St. John's Wort, may decrease the serum concentration and therapeutic effects of gefitinib.

Imatinib: St. John's Wort decreases levels of imatinib

Indinavir: St. John's Wort decreases the effect of indinavir

Methadone: St. John's Wort decreases levels/effect of methadone

Midazolam: St. John's Wort may decrease the effect of the benzodiazepine, midazolam.

Nefazodone: St. John's Wort increases the effect and toxicity of the SSRI, nefazodone.

Nelfinavir: St. John's Wort decreases the effect of indinavir

Nevirapine: St. John's Wort decreases nevirapine effect

Nifedipine: St. John's Wort decreases the effect of nifedipine

Norethindrone: St. John's Wort could reduce the contraceptive effect

Omeprazole: St. John's Wort decreases the levels/effects of omeprazole

Oxtriphylline: St. John's Wort decreases the effect of theophylline

Paroxetine: St. John's Wort increases the effect and toxicity of the SSRI, paroxetine.

Rasagiline: Increased risk of toxicity with this association

Tacrolimus: St. John's Wort may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if St. John's Wort therapy is initiated, discontinued or altered.

Temsirolimus: St. John's Wort may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.

Theophylline: St. John's Wort decreases the effect of theophylline

Tipranavir: St. John's Wort may decrease the concentration and efficacy of Tipranavir. Concomitant therapy should be avoided.

Tramadol: Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.

Tranylcypromine: Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.

Trazodone: Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.

Triazolam: St. John's Wort may decrease the effect of the benzodiazepine, triazolam.

Trimipramine: St. John's Wort may decrease serum concentrations of Trimipramine. Possible increased risk of serotonin syndrome. Monitor for changes in Trimipramine efficacy and toxicity if St. John's Wort is initiated, discontinued or dose changed.

Venlafaxine: Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.

Voriconazole: St. John's Wort may decrease the serum concentration of voriconazole by increasing its elimination. Concomitant therapy is contraindicated.

Warfarin: St. John's Wort may decrease the serum concentration of warfarin by increasing its metabolism. Concomitant therapy should be avoided. Monitor for changes in the therapeutic and adverse effects of warfarin if St. John's Wort is initiated, discontinued or dose changed.

Zolmitriptan: Use of two serotonin modulators, such as zolmitriptan and St. John's Wort, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.