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Home / Drugs / Starting with T / Thyrotropin Alfa 		 
Thyrotropin Alfa
  

Thyrotropin alfa is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
BrandsThyrogen (Genzyme Inc)
CategoriesDiagnostic Agents
ManufacturersSanofi aventis us llc
Genzyme corp
PackagersGenzyme Inc.
Organon Pharmaceuticals
SynonymsFollicle-stimulating hormone beta subunit
Follitropin beta chain precursor
FSH-B
FSH-beta

indication

For detection of residueal or recurrent thyroid cancer

pharmacology

Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. Thyrogen is an exogenous source of human TSH that offers an additional diagnostic tool in the follow-up of patients with a history of well-differentiated thyroid cancer.

mechanism of action

Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging.

half life

5 +/- 10 hrs

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