indication

Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.

pharmacology

Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate. Does not affect platelet aggregation.

mechanism of action

Inhibits prostaglandin synthesis; acts on the hypothalamus heat-regulating center to reduce fever; blocks the generation of pain impulses

toxicity

Salicylate intoxication, known as salicylism, may occur with large doses or extended therapy. Common symptoms of salicylism include headache, dizziness, tinnitus, hearing impairment, confusion, drowsiness, sweating, vomiting, diarrhea, and hyperventilation. A more severe degree of salicylate intoxication can lead to CNS disturbances, alteration in electrolyte balance, respiratory and metabolic acidosis, hyperthermia, and dehydration.

route of elimination

renal

drug interactions

Betamethasone: The corticosteroid, betamethasone, may decrease the effect of the salicylate, trisalicylate-choline.

Chlorpropamide: The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, chlorpropamide.

Fludrocortisone: The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.

Gliclazide: The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, gliclazide.

Glyburide: The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, glibenclamide.

Hydrocortisone: The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.

Methazolamide: The salicylate, trisalicylate-choline, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.

Methotrexate: The salicylate, trisalicylate-choline, increases the effect and toxicity of methotrexate.

Minocycline: Formation of non-absorbable complexes

Prednisolone: The corticosteroid, prednisolone, may decrease the effect of the salicylate, trisalicylate-choline.

Prednisone: The corticosteroid, prednisone, may decrease the effect of the salicylate, trisalicylate-choline.

Probenecid: The salicylate, trisalicylate-choline, decreases the uricosuric effect of probenecid.

Tetracycline: Formation of non-absorbable complexes

Triamcinolone: The corticosteroid, triamcinolone, may decrease the effect of the salicylate, trisalicylate-choline.

Warfarin: The antiplatelet effects of trisalicylate-choline may increase the bleed risk associated with warfarin.