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Tubocurarine |
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indicationUsed as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedurepharmacologyTubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom.mechanism of actionTubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.half life1-2 hoursdrug interactionsAmikacin: The agent increases the effect of muscle relaxantAminophylline: Theophylline decreases the effect of muscle relaxant Azathioprine: The agent decreases the effect of the muscle relaxant Carbamazepine: Decreases the effect of muscle relaxant Clindamycin: The agent increases the effect of muscle relaxant Fosphenytoin: Phenytoin decreases the effect of muscle relaxant Gentamicin: The agent increases the effect of muscle relaxant Lincomycin: The agent increases the effect of muscle relaxant Mercaptopurine: The agent dereases the effect of the muscle relaxant Netilmicin: The agent increases the effect of muscle relaxant Oxtriphylline: Theophylline decreases the effect of muscle relaxant Phenytoin: Phenytoin decreases the effect of the muscle relaxant Piperacillin: The agent increases the effect of the muscle relaxant Theophylline: Theophylline decreases the effect of the muscle relaxant Tobramycin: The agent increases the effect of the muscle relaxant |